The Exhaustion Transcription Factor That Actually Drives Antitumor Immunity
A Nature Immunology study shows TOX drives TH1 effector function in CD4+ T cells, the reverse of its exhaustion-promoting role in CD8+ T cells.
Semaglutide Fails to Slow Alzheimer's Disease in Phase 3 EVOKE Trials
The EVOKE trials found no clinical benefit from oral semaglutide in early Alzheimer's at 2 years, despite biomarker effects. What it means for GLP-1 research.
Retatrutide Cuts Weight by 28.7% and Eases Knee Pain in Phase 3 TRIUMPH-4 Trial
Retatrutide reduces body weight 28.7% and knee pain 75% in adults with obesity and osteoarthritis. Phase 3 results for a new triple hormone receptor agonist.
Red Blood Cells Deliver mRNA to Generate CAR Immune Cells In Vivo
Red blood cells can carry mRNA to the spleen to generate CAR myeloid cells in vivo, a new study shows, offering a new approach to cancer immunotherapy.
Scientists Engineer CAR-T Cells Directly in the Body — No Cell Manufacturing Required
A new Nature study describes in vivo CAR-T cell generation using targeted DNA integration in human T cells, bypassing traditional cell manufacturing.
Bacteria Inside Tumors Drive Immunotherapy Resistance in Head and Neck Cancer
Why some head and neck cancer patients fail immunotherapy despite high PD-L1 — tumor bacteria suppress T cells and recruit immunosuppressive neutrophils.
Spatial Transcriptomics Maps Immune Exclusion in Tumors
How single-cell spatial RNA mapping reveals which immune cells cluster near cancer and which are locked out—predicting immunotherapy response.
How Scientists Finally Made Helper T Cells From Stem Cells
How controlling T cell precursor commitment to CD4+ helper cells solves a 20-year barrier, enabling off-the-shelf cancer immunotherapy.
A Drug That Restores NAD+ Reverses Alzheimer's in Advanced Mouse Models
P7C3-A20 restores brain NAD+ homeostasis, reversing cognitive decline in advanced Alzheimer's mice — a challenge to the irreversibility dogma.
Spatial Omics Reveals Hidden Aggression Signals in Prostate Tumors
Spatial multi-omics identifies metabolic and immune signatures in benign-looking glands that predict aggressive prostate cancer and early relapse.
Nicheformer: A Foundation Model for Single-Cell and Spatial Omics
A new transformer foundation model trained on 110M cells reconstructs tissue architecture from dissociated single-cell data using spatial transcriptomics.
Splice-Switching Therapy for Rare Genetic Disease
Splice-switching to remove upstream open reading frames could boost protein translation in haploinsufficient rare genetic disorders.
Single-Cell Omics in Semipermeable Capsules: A New Platform
Researchers demonstrate high-throughput single-cell sequencing in semipermeable capsules, enabling cell viability and clonal tracking at scale.
Why Cancer Immunotherapy Fails: A Hidden Protein Stress Mechanism
Ohio State researchers discovered how proteotoxic stress in exhausted T cells sabotages cancer immunotherapy—and how blocking this pathway restores immune function.
Can DNA Foundation Models Beat Specialized Genomics Tools?
Benchmark of five DNA foundation models on variant prediction, gene expression, and sequence classification reveals which outperform specialized genomics tools.
Batch Harmonization Unlocks Multi-Cohort RNA Biomarker Discovery
A machine learning framework using batch correction and random forests identifies prognostic RNA signatures in pancreatic cancer across disparate datasets.
RNACOREX Maps miRNA Networks to Decode Cancer
A new Python tool finds disease-linked RNA coregulatory networks and uses them to predict cancer survival with interpretable results.
HIF-2 Controls a Hidden Hormone That Causes Lethal Calcium Imbalance in Kidney Cancer
Kidney tumors hijack a metabolic pathway to produce PTHrP, causing lethal hypercalcemia. UT Southwestern showed HIF-2 inhibitors rapidly reverse it.
ctDNA Detects High-Risk Bladder Cancer After Surgery
Circulating tumor DNA testing identifies patients who benefit from immediate immunotherapy after cystectomy, improving survival in a randomized phase 3 trial.
Multi-Omic Atlas Maps Immune Aging Across 300+ Adults
New Nature study reveals how single-cell RNA-seq, proteomics, and flow cytometry uncover age-related T cell reprogramming linked to vaccine response decline.
IFITM3 Drives Osimertinib Resistance in Lung Cancer
A new study identifies IFITM3 as a microenvironment-driven resistance mechanism in EGFR-mutant lung cancer and suggests targeting MET as a combination strategy.
CRISPR Screen Reveals UCHL5 Controls Immune Resistance in Head and Neck Cancer
In vivo CRISPR screening in head and neck cancer identifies UCHL5 as a driver of immunotherapy resistance via stromal collagen remodeling.
DNA Methylation Controls Centromere Stability
New study reveals how epigenetic marks protect centromeres from destabilization, with implications for understanding chromosomal instability in cancer.
Single-Cell Sequencing Reveals Drug Targets in Liver Cancer Resistance
A single-cell RNA-seq and AI pipeline maps tumor heterogeneity in hepatocellular carcinoma to identify targets for overcoming drug resistance.
AI Model Predicts Gene Expression with Lab Accuracy
Researchers built GEM-1, an AI system that predicts gene expression experiments with accuracy rivaling matched wet-lab replicates, using only computational methods.
HER2-Targeted Therapy Enhances Immunotherapy in Urothelial Cancer
A real-world multicenter study shows combining disitamab vedotin (an anti-HER2 ADC) with checkpoint inhibitors improves response rates in urothelial carcinoma.